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KMID : 0380020110260060569
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Korean Journal of Biotechnology and Bioengineering
2011 Volume.26 No. 6 p.569 ~ p.571
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Optimization of Reduction of 3-chloro-4-fluoropropiophenone by Whole Cells of Saccharomyces cerevisiae
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Lee Hae-Ryong
Jeong Min
Yoo Ik-Keun
Hong Soon-Ho
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Abstract
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Reduction of 3-chloro-4-fluoropropiophenone by Saccharomyces cerevisiae as a whole cell biocatalyst was optimized. Effects of glucose, S. cerevisiae and 3-chloro-4-fluoropropiophenone concentrations on conversion of reduction reaction was investigated. Optimum concentrations of glucose, S. cerevisiae and 3-chloro-4-fluoropropiophenone were 100, 40 and 20 g/L, respectively. At optimum condition, 100% of conversion was achieved in 12 hours of reaction.
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KEYWORD
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3-Chloro-4-fluoropropiophenone, Saccharomyces cerevisiae, Reduction, Biotransformation
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